486 Expression of M1- and M2-type macrophages in orofacial granulomatosis

Orofacial granulomatosis (OFG) is an uncommon disorder characterized by persistent enlargement of the soft tissues lips, oral mucosa, and area around mouth. It has uncertain etiology, but relationship with metal allergy, odontogenic infection, Crohn’s disease been reported. We report on 24 patients OFG we experienced in past 19 years between 2004 2022. They were all diagnosed histological examination. The female to male ratio was 15 9, average age 47.8 old. Involved sites lip (18), cheek (5), eyelid (6), forehead (2) jaw (1). Two had a wrinkled tongue without facial palsy. Metal allergy detected patch test 8 patients. Almost (19) treated medicines such as anti-allergic agents, minocycline, tranilast, dapsone prednisolone either alone or combination. symptoms improved patients, flared up 2 them. investigated whether macrophages infiltrating lesional skin mucosa predominantly M1 M2 using CD40, CD163, CD206 staining, tended be granuloma lesion.